Best Probiotics for IBS: The Strains With Real Evidence
The ACG and AGA conditionally recommend against probiotics for global IBS symptoms, but strain-level data by subtype is more encouraging than the headline suggests. For IBS-D, Saccharomyces boulardii CNCM I-745 and Bacillus coagulans MTCC 5856 at 2 billion CFU have the cleanest trial signals; a network meta-analysis of 43 RCTs and 5,531 patients ranked B. coagulans first overall. For IBS-C, a 2025 Frontiers in Medicine study on Bifidobacterium longum W11 showed real improvements in symptom severity and quality of life through week 8. For mixed or unclassified IBS, B. infantis 35624 at 1 x 108 CFU remains the most-studied option. Plus the 8-week trial protocol, how to read a supplement label without getting fleeced, and when a probiotic will predictably make things worse (hint: SIBO).